Symbol
Name
ID

Thrb
thyroid hormone receptor beta
MGI:98743

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type II diabetes mellitus	Increased circulating free T3	Increased circulating free T4 concentration	Increased circulating T4 concentration	Elevated circulating thyroid-stimulating hormone concentration	Goiter	Hyperthyroidism	Compensated hypothyroidism	Impaired sensitivity to thyroid hormone
Disease(s) Associated with THRB	Diabetes mellitus	Type II diabetes mellitus	Increased circulating free T3	Increased circulating free T4 concentration	Increased circulating T4 concentration		Goiter	Hyperthyroidism	Compensated hypothyroidism	Impaired sensitivity to thyroid hormone
selective pituitary thyroid hormone resistance
thyroid hormone resistance syndrome

Mouse Phenotypes

increased thyrotroph cell number

enlarged pituitary gland

abnormal thyroid follicle morphology

enlarged thyroid gland

increased thyroid gland weight

thyroid gland hyperplasia

decreased thyroid gland weight

increased pituitary adenoma incidence

increased thyroid carcinoma incidence

abnormal pituitary gland physiology

abnormal thyroid gland physiology

increased activity of thyroid gland

Availability

Mouse Genotype

Thrb^tm1.1Syc/Thrb^tm1.1Syc

Thrb^tm1Df/Thrb^tm1Df

Thrb^tm1Few/Thrb^tm1Few

Thrb^tm1Olc/Thrb^tm1Olc

Thrb^tm3Few/Thrb^tm3Few

Thrb^tm4Few/Thrb^tm4Few

Thrb^tm1.1Syc/Thrb⁺

Thrb^tm1Df/Thrb^tm1.1Syc

Thrb^tm1Mkni/Thrb^tm1Mkni
Hprt1^{tm1(TG-cre)1Sasr}/Y (conditional)

Thrb^tm1Mkni/Thrb⁺
Hprt1^{tm1(TG-cre)1Sasr}/Y (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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